On October 4, 1892, Clara Spence opened the doors of Miss Spence’s School, welcoming 10 boarding and day students to a brownstone on West 48th Street in New York City. The same year, she took legal guardianship of an orphaned child. Her growing reputation for adoption work introduced Charlotte Baker into Miss Spence’s life. Baker joined the faculty of the School, and their kinship transformed into a 25-year professional and personal partnership in running the School, sharing a passion for the care and adoption of children, creating a family of their own, and becoming exemplars of independent, influential women.